Improved skin delivery and validation of novel stability-indicating HPLC method for ketoprofen nanoemulsion
نویسندگان
چکیده
منابع مشابه
Stability Indicating HPLC Method Development and Validation
High performance liquid chromatography (HPLC) is an integral analytical tool in assessing drug product stability. HPLC methods should be able to separate, detect, and quantify the various drug-related degradants that can form on storage or manufacturing, plus detect and quantify any drug-related impurities that may be introduced during synthesis. Forced degradation studies of new chemical entit...
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A stability-indicating LC assay method was developed and validated for a simultaneous determination of meropenem and potassium clavulanate in the presence of degradation products formed during acid-base hydrolysis, oxidation and thermolysis. The isocratic RP-HPLC method was developed with a LiChrospher RP-18 (250 mm x 4.6 mm, 5 microm) column and gradient elution of 12 mmol/L ammonium acetate a...
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ژورنال
عنوان ژورنال: Arabian Journal of Chemistry
سال: 2020
ISSN: 1878-5352
DOI: 10.1016/j.arabjc.2019.09.005